The Death of Alexander the Great – A Spinal Twist of Fate

@article{Ashrafian2004TheDO,
  title={The Death of Alexander the Great – A Spinal Twist of Fate},
  author={Hutan Ashrafian},
  journal={Journal of the History of the Neurosciences},
  year={2004},
  volume={13},
  pages={138 - 142}
}
  • H. Ashrafian
  • Published 1 June 2004
  • Medicine
  • Journal of the History of the Neurosciences
Alexander the Great died in 323 B.C. from an unknown cause. Physical depictions of this historical figure reveal the likelihood of a cervical scoliotic deformity. This is substantiated with the medical history and is correlated with his untimely death. For the first time, it is concluded that Alexander’s death may have ensued from the sequelae of a congenital scoliotic syndrome. 
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References

SHOWING 1-10 OF 42 REFERENCES
Instability of the cervical spine and neurological involvement in Klippel-Feil syndrome. A case report.
Lateral radiographs made with the neck in flexion (Fig. 1-A) and in extension (Fig. I-B) demonstrate the failure of segmentation between the vertebral bodies and the posterior elements at multiple
Did Alexander the Great die of acute pancreatitis?
TLDR
The final 14 days of his life are reconstructed and the course of medical events that preceded his death with the formulation of a plausible diagnosis are recorded.
The eye injury of King Philip II and the skeletal evidence from the royal tomb II at Vergina.
TLDR
New skeletal evidence shows that the skeleton belongs to King Philip III Arrhidaeus, and the tomb may well contain some of the paraphernalia of Alexander the Great.
Craniofacial characteristics of Klippel-Feil syndrome in an eight year old female.
A female eight year, one month old patient with Klippel-Feil syndrome has been introduced. General appearance of the patient was characterized by short neck with limited head movements, craniofacial
Neurofibromatosis of the cervical spine. A report of eight cases.
TLDR
Eight patients with neurofibromatosis presented with symptoms of cervical spine involvement over a period of 17 years, five of them within the second decade of life, and good results were achieved by anterior fusion, alone, or combined with posterior fusion.
No neurological involvement for more than 40 years in Klippel-Feil syndrome with severe hypermobility of the upper cervical spine
TLDR
Early prophylactic stabilization should not be indicated for Klippel-Feil syndrome without neurological involvement only because of hypermobility, and adjacent disc problems may possibly occur at the unfused levels in the future.
Rapidly progressing quadriparesis secondary to cervical pyogenic spondylitis in a patient with Klippel-Feil syndrome.
We report a case in which the patient's quadriparesis progressed rapidly secondary to pyogenic spondylitis with an epidural abscess of the cervical spine. The patient had type II Klippel-Feil
Quadriplegia after minor trauma in the Klippel-Feil syndrome. A case report and review of the literature.
  • A. Elster
  • Medicine
    The Journal of bone and joint surgery. American volume
  • 1984
Une observation confirme que les malades atteints de syndrome de Klippel-Feil sont exposes au risque de tetraplegie apres un traumatisme minime. En presente de multiples fusions vertebrales les
Delayed cortical blindness and recurrent quadriplegia after cervical trauma.
TLDR
A 56-year-old woman with delayed cortical blindness and recurrent quadriplegia after a comminuted C1 burst fracture and a type II odontoid fracture is reported on, with marked improvement of her visual acuity and almost complete return of strength after cervical fusion and anticoagulation therapy.
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