The De Novo Cytosine Methyltransferase DRM2 Requires Intact UBA Domains and a Catalytically Mutated Paralog DRM3 during RNA–Directed DNA Methylation in Arabidopsis thaliana

@inproceedings{Henderson2010TheDN,
  title={The De Novo Cytosine Methyltransferase DRM2 Requires Intact UBA Domains and a Catalytically Mutated Paralog DRM3 during RNA–Directed DNA Methylation in Arabidopsis thaliana},
  author={Ian R. Henderson and Angelique Deleris and William Wong and Xuehua Zhong and Hang Gyeong Chin and Gregory A. Horwitz and Krystyna A. Kelly and Sriharsa Pradhan and Steven E. Jacobsen},
  booktitle={PLoS genetics},
  year={2010}
}
Eukaryotic DNA cytosine methylation can be used to transcriptionally silence repetitive sequences, including transposons and retroviruses. This silencing is stable between cell generations as cytosine methylation is maintained epigenetically through DNA replication. The Arabidopsis thaliana Dnmt3 cytosine methyltransferase ortholog DOMAINS rearranged… CONTINUE READING