The DNA translocase FANCM/MHF promotes replication traverse of DNA interstrand crosslinks.

@article{Huang2013TheDT,
  title={The DNA translocase FANCM/MHF promotes replication traverse of DNA interstrand crosslinks.},
  author={Junji Huang and Shuo Liu and Marina A. Bellani and Arun Kalliat Thazhathveetil and Chen Ling and Johan P. de Winter and Yinsheng Wang and Weidong Wang and Michael M. Seidman},
  journal={Molecular cell},
  year={2013},
  volume={52 3},
  pages={434-46}
}
The replicative machinery encounters many impediments, some of which can be overcome by lesion bypass or replication restart pathways, leaving repair for a later time. However, interstrand crosslinks (ICLs), which preclude DNA unwinding, are considered absolute blocks to replication. Current models suggest that fork collisions, either from one or both sides of an ICL, initiate repair processes required for resumption of replication. To test these proposals, we developed a single-molecule… CONTINUE READING
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