The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-β during Chlamydia trachomatis infection.

@article{Zhang2014TheDS,
  title={The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-β during Chlamydia trachomatis infection.},
  author={Yugen Zhang and Laxmi Yeruva and Anthony D. Marinov and Daniel Prantner and Priscilla B. Wyrick and Vladimir V Lupashin and Uma M. Nagarajan},
  journal={Journal of immunology},
  year={2014},
  volume={193 5},
  pages={
          2394-404
        }
}
  • Yugen Zhang, Laxmi Yeruva, +4 authors Uma M. Nagarajan
  • Published in Journal of immunology 2014
  • Biology, Medicine
  • IFN-β has been implicated as an effector of oviduct pathology resulting from genital chlamydial infection in the mouse model. In this study, we investigated the role of cytosolic DNA and engagement of DNA sensors in IFN-β expression during chlamydial infection. We determined that three-prime repair exonuclease-1, a host 3' to 5' exonuclease, reduced IFN-β expression significantly during chlamydial infection using small interfering RNA and gene knockout fibroblasts, implicating cytosolic DNA as… CONTINUE READING

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