The DNA revolution in population genetics.


Unprecedental clarity has come to our understanding of genetic variation by the analysis of DNA sequences. It is not surprising that the new DNA technologies are leading to a resurgence of interest in population genetics. In this review, I discuss recent progress and future directions towards reconstructing the history of human populations. There is increasing consensus on a recent 'Out of Africa' origin of modern humans, which explains why the greatest fraction of genetic diversity is found within populations, rather than between them. The comparison of Y chromosome and mitochondrial DNA data shows remarkable sex differences in geographic variation. The analysis of Neanderthal DNA has been a major breakthrough in the study of fossil DNA. Among major hopes for the future are application to polygenic diseases.


Citations per Year

1,196 Citations

Semantic Scholar estimates that this publication has 1,196 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{CavalliSforza1998TheDR, title={The DNA revolution in population genetics.}, author={Luca L. Cavalli-Sforza}, journal={Trends in genetics : TIG}, year={1998}, volume={14 2}, pages={60-5} }