The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovarian cancer.

@article{Weberpals2009TheDR,
  title={The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovarian cancer.},
  author={Johanne I. Weberpals and Kyla D Garbuio and Anna M. O'Brien and Katherine V. Clark-Knowles and Steve Doucette and Olga Antoniouk and Glenwood Goss and Jim Dimitroulakos},
  journal={International journal of cancer},
  year={2009},
  volume={124 4},
  pages={
          806-15
        }
}
This study compares Breast Cancer 1 (BRCA1) and excision repair cross complementation group 1 (ERCC1) expression as predictive markers and evaluates the in vitro enhancement of platinum sensitivity using targeted agents in sporadic ovarian cancer (OC). A retrospective study was performed of advanced stage OC patients receiving platinum-based chemotherapy. BRCA1 and ERCC1 mRNA expression was determined from frozen tissue of 51 patients. Median overall survival (OS) was longer for patients with… CONTINUE READING
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