The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome.

@article{Trego2011TheDR,
  title={The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome.},
  author={Kelly S. Trego and Sophia B. Chernikova and Albert R. Davalos and J. Jefferson P. Perry and L David Finger and Cliff Ng and Miaw-sheue Tsai and Steven M. Yannone and John A. Tainer and Judith Campisi and Priscilla K. Cooper},
  journal={Cell cycle},
  year={2011},
  volume={10 12},
  pages={1998-2007}
}
XPG is a structure-specific endonuclease required for nucleotide excision repair (NER). XPG incision defects result in the cancer-prone syndrome xeroderma pigmentosum, whereas truncating mutations of XPG cause the severe postnatal progeroid developmental disorder Cockayne syndrome. We show that XPG interacts directly with WRN protein, which is defective in the premature aging disorder Werner syndrome, and that the two proteins undergo similar subnuclear redistribution in S phase and colocalize… CONTINUE READING
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