The DNA methylation landscape of human melanoma.

  title={The DNA methylation landscape of human melanoma.},
  author={Seung-gi Jin and Wenying Xiong and Xiwei Wu and Lu Yang and Gerd. P. Pfeifer},
  volume={106 6},
Using MIRA-seq, we have characterized the DNA methylome of metastatic melanoma and normal melanocytes. Individual tumors contained several thousand hypermethylated regions. We discovered 179 tumor-specific methylation peaks present in all (27/27) melanomas that may be effective disease biomarkers, and 3113 methylation peaks were seen in >40% of the tumors. We found that 150 of the approximately 1200 tumor-associated methylation peaks near transcription start sites (TSSs) were marked by H3K27me3… CONTINUE READING
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