The DNA methylation landscape of human melanoma.

@article{Jin2015TheDM,
  title={The DNA methylation landscape of human melanoma.},
  author={Seung-gi Jin and Wenying Xiong and Xiwei Wu and Lu Yang and Gerd. P. Pfeifer},
  journal={Genomics},
  year={2015},
  volume={106 6},
  pages={322-30}
}
Using MIRA-seq, we have characterized the DNA methylome of metastatic melanoma and normal melanocytes. Individual tumors contained several thousand hypermethylated regions. We discovered 179 tumor-specific methylation peaks present in all (27/27) melanomas that may be effective disease biomarkers, and 3113 methylation peaks were seen in >40% of the tumors. We found that 150 of the approximately 1200 tumor-associated methylation peaks near transcription start sites (TSSs) were marked by H3K27me3… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.