The DNA methylation landscape of human early embryos

@article{Guo2014TheDM,
  title={The DNA methylation landscape of human early embryos},
  author={Hongshan Guo and Ping Zhu and Liying Yan and Rong Li and Boqiang Hu and Ying Lian and Jie Yan and Xiulian Ren and Shengli Lin and Junsheng Li and Xiaohu Jin and Xiaodan Shi and Ping Liu and Xiaoye May Wang and Wei Wang and Yuan Wei and Xianlong Li and Fan Guo and Xinglong Wu and Xiaoying Fan and Jun Yong and Lu Wen and Sunney X. Xie and Fuchou Tang and Jie Qiao},
  journal={Nature},
  year={2014},
  volume={511},
  pages={606-610}
}
DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic development. However, its dynamic patterns have not been analysed at the genome scale in human pre-implantation embryos due to technical difficulties and the scarcity of required materials. Here we systematically profile the methylome of human early embryos from the zygotic stage through to post-implantation by reduced representation bisulphite sequencing and whole-genome bisulphite sequencing. We show that… CONTINUE READING
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