The DNA methylation landscape of human early embryos

  title={The DNA methylation landscape of human early embryos},
  author={Hongshan Guo and P. Zhu and Liying Yan and R. Li and Boqiang Hu and Y. Lian and J. Yan and Xiulian Ren and S. Lin and Junsheng Li and Xiaohu Jin and Xiaodan Shi and Ping Liu and X. Wang and W. Wang and Yuan Wei and X. Li and F. Guo and X. Wu and Xiaoying Fan and Jun Yong and L. Wen and S. X. Xie and F. Tang and J. Qiao},
  • Hongshan Guo, P. Zhu, +22 authors J. Qiao
  • Published 2014
  • Medicine, Biology
  • Nature
  • DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic development. However, its dynamic patterns have not been analysed at the genome scale in human pre-implantation embryos due to technical difficulties and the scarcity of required materials. Here we systematically profile the methylome of human early embryos from the zygotic stage through to post-implantation by reduced representation bisulphite sequencing and whole-genome bisulphite sequencing. We show that… CONTINUE READING
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