The DNA methylation landscape of giant viruses

  title={The DNA methylation landscape of giant viruses},
  author={Sandra Jeudy and Sofia Rigou and Jean-Marie Alempic and Jean-Michel Claverie and Chantal Abergel and Matthieu Legendre},
  journal={Nature Communications},
DNA methylation is an important epigenetic mark that contributes to various regulations in all domains of life. Giant viruses are widespread dsDNA viruses with gene contents overlapping the cellular world that also encode DNA methyltransferases. Yet, virtually nothing is known about the methylation of their DNA. Here, we use single-molecule real-time sequencing to study the complete methylome of a large spectrum of giant viruses. We show that DNA methylation is widespread, affecting 2/3 of the… 
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Beyond Watson and Crick: DNA Methylation and Molecular Enzymology of DNA Methyltransferases
  • A. Jeltsch
  • Biology, Chemistry
    Chembiochem : a European journal of chemical biology
  • 2002
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