The DNA helicase-primase complex as a target for herpes viral infection.

@article{Weller2013TheDH,
  title={The DNA helicase-primase complex as a target for herpes viral infection.},
  author={Sandra K Weller and Robert D. Kuchta},
  journal={Expert opinion on therapeutic targets},
  year={2013},
  volume={17 10},
  pages={1119-32}
}
INTRODUCTION The Herpesviridae are responsible for debilitating acute and chronic infections, and some members of this family are associated with human cancers. Conventional anti-herpesviral therapy targets the viral DNA polymerase and has been extremely successful; however, the emergence of drug-resistant virus strains, especially in neonates and immunocompromised patients, underscores the need for continued development of anti-herpes drugs. In this article, we explore an alternative target… CONTINUE READING