The DNA double-strand “breakome” of mouse spermatids

  title={The DNA double-strand “breakome” of mouse spermatids},
  author={Marie-Chantal Gr{\'e}goire and Fr{\'e}d{\'e}ric Leduc and Martin H. Morin and Tiphanie Cav{\'e} and M{\'e}lina Arguin and Martin Richter and Pierre-{\'E}tienne Jacques and Guylain Boissonneault},
  journal={Cellular and Molecular Life Sciences},
De novo germline mutations arise preferentially in male owing to fundamental differences between spermatogenesis and oogenesis. Post-meiotic chromatin remodeling in spermatids results in the elimination of most of the nucleosomal supercoiling and is characterized by transient DNA fragmentation. Using three alternative methods, DNA from sorted populations of… CONTINUE READING