The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis.

@article{Jette2015TheDP,
  title={The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis.},
  author={Nicholas Jette and Susan P Lees-Miller},
  journal={Progress in biophysics and molecular biology},
  year={2015},
  volume={117 2-3},
  pages={194-205}
}
The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the past two decades, significant progress has been made in elucidating the role of DNA-PK in non-homologous end joining (NHEJ), the major pathway for repair of ionizing radiation-induced DNA double strand breaks in human cells and recently, additional roles for DNA-PK have been reported. In this review, we will describe the… CONTINUE READING