The DNA-dependent ATPase activity of vaccinia virus early gene transcription factor is essential for its transcription activation function.

@article{Li1993TheDA,
  title={The DNA-dependent ATPase activity of vaccinia virus early gene transcription factor is essential for its transcription activation function.},
  author={Ji-liang Li and Steven S. Broyles},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 27},
  pages={20016-21}
}
Vaccinia virus early transcription factor (VETF) activates the transcription of early gene templates by the viral RNA polymerase. VETF is a heterodimeric protein that binds to transcription promoters and has an associated DNA-dependent ATPase activity. The small subunit of VETF has sequences resembling two motifs commonly found in ATPases: an A-type ATP binding motif and a DEAH box. To investigate the functional role of the ATPase activity, we have analyzed the effect of mutations in each of… CONTINUE READING