The DNA demethylating agent 5-aza-2'-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells.

@article{Almstedt2010TheDD,
  title={The DNA demethylating agent 5-aza-2'-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells.},
  author={Maika Almstedt and Nadja Blagitko-Dorfs and Jes{\'u}s Duque-Afonso and Julia Karbach and Dietmar Pfeifer and E. P. Jaeger and Michael Luebbert},
  journal={Leukemia research},
  year={2010},
  volume={34 7},
  pages={899-905}
}
Azanucleoside DNA-hypomethylating agents have remarkable clinical activity in myelodysplastic syndromes and acute myeloid leukemia (AML), particularly at low, non-cytotoxic doses favoring hypomethylation over cytotoxicity. Cancer/testis antigens (CTAs) encoding immunogenic proteins are not expressed in almost all normal tissues and many tumor types, but are consistently derepressed by epigenetically active agents in various cancer cell lines. Since the expression of CTA genes is usually very… CONTINUE READING

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