The DNA damage response: putting checkpoints in perspective

  title={The DNA damage response: putting checkpoints in perspective},
  author={B S Zhou and Stephen J Elledge},
The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks. 
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