The DNA-damage response: new molecular insights and new approaches to cancer therapy.

@article{Jackson2009TheDR,
  title={The DNA-damage response: new molecular insights and new approaches to cancer therapy.},
  author={Stephen P. Jackson},
  journal={Biochemical Society transactions},
  year={2009},
  volume={37 Pt 3},
  pages={483-94}
}
The DNA of all cells is continually under assault from a wide range of DNA-damaging agents. To counter this threat to their genetic integrity, cells possess systems, collectively known as the DDR (DNA-damage response), to detect DNA damage, signal its presence and mediate its repair. In the present article, I provide an overview of the DDR and then describe how work in my laboratory and elsewhere has identified some of the key protein players that mediate cellular responses to the most… CONTINUE READING

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