The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

@article{Gasser2005TheDD,
  title={The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor},
  author={Stephan Gasser and Sandra Orsulic and Eric J. Brown and David H Raulet},
  journal={Nature},
  year={2005},
  volume={436},
  pages={1186-1190}
}
Some stimulatory receptors of the innate immune system, such as the NKG2D receptor (also called KLRK1) expressed by natural killer cells and activated CD8+T cells, recognize self-molecules that are upregulated in diseased cells by poorly understood mechanisms. Here we show that mouse and human NKG2D ligands are upregulated in non-tumour cell lines by genotoxic stress and stalled DNA replication, conditions known to activate a major DNA damage checkpoint pathway initiated by ATM (ataxia… CONTINUE READING
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