The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins

@article{Kuip1999TheDS,
  title={The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins},
  author={H. van der Kuip and B. Carius and S. J. Haque and B. Williams and C. Huber and T. Fischer},
  journal={Journal of Molecular Medicine},
  year={1999},
  volume={77},
  pages={386-392}
}
The DNA-binding subunit of replication factor C (RFCp140) plays an important role in both DNA replication and DNA repair. The mechanisms regulating activation of RFCp140 thereby controlling replication and cellular proliferation are largely unknown. We analyzed protein expression of RFCp140 during cell cycle progression and investigated the association of RFCp140 with cell cycle regulatory proteins in cell lines of various tissue origin and in primary hematopoietic cells. Western and Northern… Expand
The Second Subunit of the Replication Factor C complex (RFC40) and the Regulatory Subunit (RI?) of Protein Kinase A form a Protein Complex Promoting Cell Survival
TLDR
Using RFC40 as the bait in a yeast two-hybrid screening, it is identified a novel interaction between RFC40 and the regulatory subunit (RI?) of cAMP-dependent Protein kinase A (PKA) that led to reduction in the amount of RFC40-RI? complex, together with decrease in cell survival. Expand
Replication Factor C Recruits DNA Polymerase δ to Sites of Nucleotide Excision Repair but Is Not Required for PCNA Recruitment
TLDR
It is shown that replication factor C (RFC) is implicated in postincision NER in mammalian cells and speculated that RFC associates with the downstream 5′ phosphate after loading; such interaction would prevent possible signaling events initiated by the RFC-like Rad17 and may assist in unloading of PCNA. Expand
Mammalian Development and Cancer: A Brief History of Mice Lacking D-Type Cyclins or CDK4/CDK6
TLDR
This chapter summarizes the history of mice lacking D cyclins and CDK4/CDK6 and presents a synopsis of key findings from those animal models, often linking tissue-specific functions to antineoplastic effects of inhibition of cyclin-D-dependent processes. Expand
Human DNA repair genes
TLDR
The current status of what is known about the DNA repair genes is tabulated, limited to genes whose function is directly related to DNA repair. Expand
Proteomic identification of a direct role for cyclin d1 in DNA damage repair.
TLDR
Recent findings show a cyclin D1 function in homologous recombination-mediated DNA repair, which is consistent with the cell-cycle role of the protein in cancer cells. Expand
Proteomic Identi fi cation of a Direct Role for Cyclin D 1 in DNA Damage Repair
The human CCND1 gene, which encodes the cell-cycle protein cyclin D1, is one of the most frequently amplified genes in human cancers. Cyclin D1 activates the cyclin-dependent kinases CDK4 and CDK6Expand
In BCR-ABL-positive cells, STAT-5 tyrosine-phosphorylation integrates signals induced by imatinib mesylate and Ara-C
TLDR
It is demonstrated that STAT-5 tyrosine-phosphorylation is a specific target of imatinib mesylate and Ara-C and may be responsible for synergistic or additive effects on BCR-ABL-positive cells. Expand
Oxygen regulation of arterial smooth muscle cell proliferation and survival.
  • J. B. Ray, S. Arab, +4 authors M. Ward
  • Biology, Medicine
  • American journal of physiology. Heart and circulatory physiology
  • 2008
TLDR
It is concluded that hypoxia induces a state of enhanced cell turnover through increased rates of both smooth muscle cell proliferation and death, which confers the ability to remodel the vasculature in response to changing tissue metabolic needs while avoiding the accumulation of mutations that may lead to malignant transformation or the formation of abnormal vascular structures. Expand
Response Proliferative Capacity of Undifferentiated Stem Cells of Obtained Human Adult Dental Follicle
TLDR
It is concluded that the culture remained stable during the 25 days of culture, presenting the markers of stem cells and markers of control, progression, and cell proliferation that there was an increased production of lipid peroxides between the 6th and 12th days; this increase is related to the increased numbers of cells that also occurs during this period. Expand

References

SHOWING 1-10 OF 37 REFERENCES
Functions of replication factor C and proliferating-cell nuclear antigen: functional similarity of DNA polymerase accessory proteins from human cells and bacteriophage T4.
  • T. Tsurimoto, B. Stillman
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1990
TLDR
A striking conservation of the DNA replication apparatus in human cells and bacteriophage T4 is demonstrated. Expand
Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme.
TLDR
It is shown that Cip1 efficiently inhibits simian virus 40 replication dependent upon pol alpha, activator 1, PCNA, and pol delta, and this inhibition can be overcome by additional PCNA. Expand
Deletion Analysis of the Large Subunit p140 in Human Replication Factor C Reveals Regions Required for Complex Formation and Replication Activities*
TLDR
To characterize the role of the large subunit p140 in the function of the RFC complex, deletion mutants were created that defined a region within the p140 C terminus required for complex formation with the four small subunits. Expand
Structure-Function Relationship of the Eukaryotic DNA Replication Factor, Proliferating Cell Nuclear Antigen (*)
TLDR
The functional domains of human PCNA required for stimulation of replication factor C (RF-C) ATPase and DNA synthesis by pol δ are studied, suggesting that short deletions from either the N or C termini caused drastic changes in extraction and chromatographic behaviors. Expand
The large subunit of replication factor C (Rfc1p/Cdc44p) is required for DNA replication and DNA repair in Saccharomyces cerevisiae.
TLDR
It is demonstrated that Cdc44p is required for both DNA replication and DNA repair in vivo, and plays an important role in both DNA replicated and repaired in vivo. Expand
Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts.
TLDR
Down-regulation of cyclin D1 is necessary for PCNA relocation and repair DNA synthesis as well as for the start of DNA replication, indicating that it appears to be an essential component of a G1-checkpoint. Expand
Saccharomyces cerevisiae replication factor C. II. Formation and activity of complexes with the proliferating cell nuclear antigen and with DNA polymerases delta and epsilon.
  • P. Burgers
  • Medicine, Biology
  • The Journal of biological chemistry
  • 1991
TLDR
It is suggested that ATP binding promotes the formation of a labile complex of RF-C with PCNA at the primer terminus, whereas its hydrolysis is required to form a stable complex. Expand
Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4.
The product (pRb) of the retinoblastoma gene (RB-1) prevents S-phase entry during the cell cycle, and inactivation of this growth-suppressive function is presumed to result from pRbExpand
Overexpression of mouse p140 subunit of replication factor C accelerates cellular proliferation.
TLDR
The stable clones exhibited significantly accelerated cell proliferation, indicating that RFC-p140 is the limiting subunit of an active RFC complex in normal cells. Expand
Identification of Regions within the Four Small Subunits of Human Replication Factor C Required for Complex Formation and DNA Replication*
TLDR
To study the individual subunits in the RFC complex and the role of the RFC boxes, deletion mutations were created in all subunits, suggesting unique functions for theindividual subunits. Expand
...
1
2
3
4
...