The DNA-binding protein HU has a regulatory role in the acid stress response mechanism in Helicobacter pylori.

@article{Almarza2015TheDP,
  title={The DNA-binding protein HU has a regulatory role in the acid stress response mechanism in Helicobacter pylori.},
  author={Oscar Almarza and Daniel Nunez and H{\'e}ctor Toledo},
  journal={Helicobacter},
  year={2015},
  volume={20 1},
  pages={29-40}
}
BACKGROUND Bacterial genomes are compacted by association with histone-like proteins to form a complex known as bacterial chromatin. The histone-like protein HU is capable of binding and bending the DNA molecule, a function related to compaction, protection, and regulation of gene expression. In Helicobacter pylori, HU is the only histone-like protein described so far. Proteomic analysis from our laboratory showed that this protein is overexpressed under acidic stress. MATERIALS AND METHODS… CONTINUE READING