The DNA-binding protein CTCF limits proximal Vκ recombination and restricts κ enhancer interactions to the immunoglobulin κ light chain locus.

@article{Almeida2011TheDP,
  title={The DNA-binding protein CTCF limits proximal Vκ recombination and restricts κ enhancer interactions to the immunoglobulin κ light chain locus.},
  author={Claudia Ribeiro de Almeida and Ralph Stadhouders and Marjolein J. W. de Bruijn and Ingrid M. Bergen and Supat Thongjuea and Boris Lenhard and Wilfred F J van Ijcken and Frank Grosveld and Niels Galjart and Eric Soler and Rudi W Hendriks},
  journal={Immunity},
  year={2011},
  volume={35 4},
  pages={501-13}
}
Regulation of immunoglobulin (Ig) V(D)J gene rearrangement is dependent on higher-order chromatin organization. Here, we studied the in vivo function of the DNA-binding zinc-finger protein CTCF, which regulates interactions between enhancers and promoters. By conditional deletion of the Ctcf gene in the B cell lineage, we demonstrate that loss of CTCF allowed Ig heavy chain recombination, but pre-B cell proliferation and differentiation was severely impaired. In the absence of CTCF, the Ig… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Similar Papers

Loading similar papers…