The DNA binding pattern of the retinoid X receptor is regulated by ligand-dependent modulation of its oligomeric state.

@article{Kersten1997TheDB,
  title={The DNA binding pattern of the retinoid X receptor is regulated by ligand-dependent modulation of its oligomeric state.},
  author={Sander Kersten and Hinrich Gronemeyer and Noa Noy},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 19},
  pages={12771-7}
}
The retinoid X receptor (RXR) regulates target gene transcription via its association with cognate DNA response elements either as a homodimer or as a heterodimer with a number of other nuclear receptors. We previously demonstrated that, in solution, RXR forms tetramers with a high affinity and that ligand binding leads to dissociation of receptor tetramers to smaller species. Here it is shown that RXR tetramers form stable complexes with direct repeats (DR-1 or DR-5) or palindromic (TREpal… CONTINUE READING