The DNA-binding network of Mycobacterium tuberculosis

  title={The DNA-binding network of Mycobacterium tuberculosis},
  author={Kyle J. Minch and Tige R. Rustad and Eliza J. R. Peterson and Jessica K. Winkler and David J. Reiss and Shuyi Ma and Mark J. Hickey and William Brabant and Bob Morrison and Serdar Turkarslan and Chris Mawhinney and James E. Galagan and Nathan D. Price and Nitin S. Baliga and David R. Sherman},
  journal={Nature Communications},
Mycobacterium tuberculosis (MTB) infects 30% of all humans and kills someone every 20–30 s. Here we report genome-wide binding for ~80% of all predicted MTB transcription factors (TFs), and assayed global expression following induction of each TF. The MTB DNA-binding network consists of ~16,000 binding events from 154 TFs. We identify >50 TF-DNA consensus motifs and >1,150 promoter-binding events directly associated with proximal gene regulation. An additional ~4,200 binding events are in… 

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