The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice

@article{Oneil2001TheDB,
  title={The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice},
  author={J O'neil and Marilisa Billa and Sarah R. Oikemus and Michelle Kelliher},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={3897-3905}
}
Activation of the basic helix–loop–helix (bHLH) gene TAL-1 (or SCL) is the most frequent gain-of-function mutation in pediatric T cell acute lymphoblastic leukemia (T-ALL). Similarly, mis-expression of tal-1 in the thymus of transgenic mice results in the development of clonal T cell lymphoblastic leukemia. To determine the mechanism(s) of tal-1-induced leukemogenesis, we created transgenic mice expressing a DNA binding mutant of tal-1. Surprisingly, these mice develop disease, demonstrating… CONTINUE READING
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