The DNA Replication Stress Hypothesis of Alzheimer's Disease

  title={The DNA Replication Stress Hypothesis of Alzheimer's Disease},
  author={Yuri B. Yurov and Svetlana G. Vorsanova and Ivan Y. Iourov},
A well-recognized theory of Alzheimer's disease (AD) pathogenesis suggests ectopic cell cycle events to mediate neurodegeneration. Vulnerable neurons of the AD brain exhibit biomarkers of cell cycle progression and DNA replication suggesting a reentry into the cell cycle. Chromosome reduplication without proper cell cycle completion and mitotic division probably causes neuronal cell dysfunction and death. However, this theory seems to require some inputs in accordance with the generally… CONTINUE READING
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