The DNA–protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations

  title={The DNA–protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations},
  author={R. Liu and J. Qiu and L. Finger and L. Zheng and B. Shen},
  journal={Nucleic Acids Research},
  pages={1772 - 1784}
  • R. Liu, J. Qiu, +2 authors B. Shen
  • Published 2006
  • Biology, Medicine
  • Nucleic Acids Research
  • Flap endonuclease-1 (FEN-1) is a structure-specific nuclease best known for its involvement in RNA primer removal and long-patch base excision repair. This enzyme is known to possess 5′-flap endo- (FEN) and 5′–3′ exo- (EXO) nuclease activities. Recently, FEN-1 has been reported to also possess a gap endonuclease (GEN) activity, which is possibly involved in apoptotic DNA fragmentation and the resolution of stalled DNA replication forks. In the current study, we compare the kinetics of these… CONTINUE READING
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