The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.

@article{Krentz2009TheDD,
  title={The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.},
  author={Anthony D. Krentz and Mark W. Murphy and Shinseog Kim and Matthew Simon Cook and Blanche Capel and Rui Zhu and Angabin Matin and Aaron L. Sarver and Keith L. Parker and Michael D Griswold and Leendert H. J. Looijenga and Vivian J. Bardwell and David A. Zarkower},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 52},
  pages={22323-8}
}
Dmrt1 (doublesex and mab-3 related transcription factor 1) is a conserved transcriptional regulator of male differentiation required for testicular development in vertebrates. Here, we show that in mice of the 129Sv strain, loss of Dmrt1 causes a high incidence of teratomas, whereas these tumors do not form in Dmrt1 mutant C57BL/6J mice. Conditional gene targeting indicates that Dmrt1 is required in fetal germ cells but not in Sertoli cells to prevent teratoma formation. Mutant 129Sv germ cells… CONTINUE READING
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