The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes.

@article{Macedo2003TheDM,
  title={The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes.},
  author={Maria G Macedo and Burcu Anar and Iraad F. Bronner and Milena Cannella and Ferdinando Squitieri and Vincenzo Bonifati and Andr{\'e} T. Hoogeveen and Peter Heutink and Patrizia Rizzu},
  journal={Human molecular genetics},
  year={2003},
  volume={12 21},
  pages={2807-16}
}
Parkinson's disease (PD) is a common neurodegenerative disorder that involves the selective degeneration of midbrain dopaminergic neurons. Recently DJ-1 mutations have been linked to autosomal-recessive early-onset Parkinsonism in two European families. By using gel filtration assays under physiological conditions we demonstrate that DJ-1 protein forms a dimeric structure. Conversely, the DJ-1L166P mutant protein shows a different elution profile as compared with DJ-1WT both in overexpression… CONTINUE READING
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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

  • V. Bonifati, P. Rizzu, +7 authors M Joosse
  • 2003
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