The DIVa maturase binding site in the yeast group II intron aI2 is essential for intron homing but not for in vivo splicing.

@article{Huang2003TheDM,
  title={The DIVa maturase binding site in the yeast group II intron aI2 is essential for intron homing but not for in vivo splicing.},
  author={H C Huang and Michael Y. Chao and Barbara Armstrong and Yong Wang and Alan M. Lambowitz and Philip S. Perlman},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 23},
  pages={8809-19}
}
Splicing of the Saccharomyces cerevisiae mitochondrial DNA group II intron aI2 depends on the intron-encoded 62-kDa reverse transcriptase-maturase protein (p62). In wild-type strains, p62 remains associated with the excised intron lariat RNA in ribonucleoprotein (RNP) particles that are essential for intron homing. Studies of a bacterial group II intron showed that the DIVa substructure of intron domain IV is a high-affinity binding site for its maturase. Here we first present in vitro evidence… CONTINUE READING
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