The DHH1/RCKp54 family of helicases: an ancient family of proteins that promote translational silencing.

@article{Presnyak2013TheDF,
  title={The DHH1/RCKp54 family of helicases: an ancient family of proteins that promote translational silencing.},
  author={Vlad Presnyak and Jeff Coller},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1829 8},
  pages={817-23}
}
Translational control is a vital aspect of gene expression. Message specific translational repressors have been known for decades. Recent evidence, however, suggests that a general machinery exists that dampens the translational capacity of the majority of mRNAs. This activity has been best ascribed to a conserved family of RNA helicases called the DHH1/RCKp54 family. The function of these helicases is to promote translational silencing. By transitioning mRNA into quiescence, DHH1/RCKp54… CONTINUE READING

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