The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans.

@article{Kantartzis2009TheDG,
  title={The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans.},
  author={Konstantinos Kantartzis and Fausto Machicao and J{\"u}rgen Machann and Fritz Schick and Andreas Fritsche and H. U. H{\"a}ring and Norbert Stefan},
  journal={Clinical science},
  year={2009},
  volume={116 6},
  pages={
          531-7
        }
}
The enzyme DGAT (acyl-CoA:diacylglycerol acyltransferase) catalyses the final step of triacylglycerol (triglyceride) synthesis. Mice overexpressing hepatic DGAT2 fed a high-fat diet develop fatty liver, but not insulin resistance, suggesting that DGAT2 induces a dissociation between fatty liver and insulin resistance. In the present study, we investigated whether such a phenotype also exists in humans. For this purpose, we determined the relationships between genetic variability in the DGAT2… 
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TLDR
The most recent studies demonstrating the key role of DNL in NAFLD development are presented and a special focus will be made on desaturases especially the stearoyl CoA desaturase 1, a central enzyme implicated in fatty liver disease as well as on the delta 5 and delta 6 desaturased, two enzymes involved in the synthesis of omega 3 and omega 6 fatty acids.
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The liver as an endocrine organ - linking NAFLD and insulin resistance.
TLDR
The NAFLD-induced changes in secretion of liver proteins, lipids, other metabolites, and miRNAs are described, and how these molecules alter metabolism in liver, muscle, adipose tissue and pancreas to induce insulin resistance is described.
Triglyceride Metabolism in the Liver.
TLDR
The current understanding of fatty acid and triglyceride metabolism in the liver and its regulation in health and disease is described, identifying potential directions for future research.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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