The DEAH-Box RNA Helicase DHX15 Activates NF-kB and MAPK Signaling Downstream of MAVS During Antiviral Responses

Abstract

During infection with an RNA virus, the DExD/H-box RNA helicases RIG-I (retinoic acid–inducible gene I) and MDA5 (melanoma differentiation–associated gene 5) activate the interferon regulatory factor 3 (IRF3), nuclear factor kB (NF-kB), c-Jun amino-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) signaling pathways through an unknown… (More)

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