The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response

@article{Soulat2008TheDH,
  title={The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response},
  author={D. Soulat and Tilmann B{\"u}rckst{\"u}mmer and Sandra Westermayer and Adriana R. Gonçalves and Angela Bauch and Adrijana Stefanovic and Oliver Hantschel and Keiryn L. Bennett and Thomas Decker and Giulio Superti-Furga},
  journal={The EMBO Journal},
  year={2008},
  volume={27},
  pages={2135 - 2146}
}
TANK-binding kinase 1 (TBK1) is of central importance for the induction of type-I interferon (IFN) in response to pathogens. We identified the DEAD-box helicase DDX3X as an interaction partner of TBK1. TBK1 and DDX3X acted synergistically in their ability to stimulate the IFN promoter, whereas RNAi-mediated reduction of DDX3X expression led to an impairment… CONTINUE READING