The DEAD-Box Protein DP103 (Ddx20 or Gemin-3) Represses Orphan Nuclear Receptor Activity via SUMO Modification

@article{Lee2005TheDP,
  title={The DEAD-Box Protein DP103 (Ddx20 or Gemin-3) Represses Orphan Nuclear Receptor Activity via SUMO Modification},
  author={Martin B Lee and L. Lebedeva and M. Suzawa and S. Wadekar and M. Desclozeaux and H. Ingraham},
  journal={Molecular and Cellular Biology},
  year={2005},
  volume={25},
  pages={1879 - 1890}
}
  • Martin B Lee, L. Lebedeva, +3 authors H. Ingraham
  • Published 2005
  • Medicine, Biology
  • Molecular and Cellular Biology
  • ABSTRACT Structural analysis of nuclear receptor subfamily V orphan nuclear receptors suggests that ligand-independent mechanisms must regulate this subclass of receptors. Here, we report that steroidogenic factor 1 (SF-1) and liver receptor homolog 1 are repressed via posttranslational SUMO modification at conserved lysines within the hinge domain. Indeed, mutating these lysines or adding the SUMO isopeptidase SENP1 dramatically increased both native and Gal4-chimera receptor activities. The… CONTINUE READING
    Decreased Recognition of SUMO-Sensitive Target Genes following Modification of SF-1 (NR5A1)
    56
    Transcriptional Suppression by Transient Recruitment of ARIP4 to Sumoylated nuclear receptor Ad4BP/SF-1.
    18
    SUMOylation Inhibits SF-1 Activity by Reducing CDK7-Mediated Serine 203 Phosphorylation
    58

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 52 REFERENCES
    The DEAD box protein DP103 is a regulator of steroidogenic factor-1.
    79
    A Novel Domain within the DEAD-Box Protein DP103 Is Essential for Transcriptional Repression and Helicase Activity
    70