The DDX6–4E-T interaction mediates translational repression and P-body assembly

  title={The DDX6–4E-T interaction mediates translational repression and P-body assembly},
  author={Anastasiia Kamenska and Clare V Simpson and Caroline Vindry and Helen Broomhead and Marianne Benard and Mich{\`e}le Ernoult-Lange and B. P. Lee and Lorna W Harries and D. Weil and Nancy Standart},
  booktitle={Nucleic acids research},
4E-Transporter binds eIF4E via its consensus sequence YXXXXLΦ, shared with eIF4G, and is a nucleocytoplasmic shuttling protein found enriched in P-(rocessing) bodies. 4E-T inhibits general protein synthesis by reducing available eIF4E levels. Recently, we showed that 4E-T bound to mRNA however represses its translation in an eIF4E-independent manner, and contributes to silencing of mRNAs targeted by miRNAs. Here, we address further the mechanism of translational repression by 4E-T by first… CONTINUE READING
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