The DDAH/ADMA pathway is a critical regulator of NO signalling in vascular homeostasis.

@article{Fiedler2008TheDP,
  title={The DDAH/ADMA pathway is a critical regulator of NO signalling in vascular homeostasis.},
  author={Lorna R. Fiedler},
  journal={Cell adhesion & migration},
  year={2008},
  volume={2 3},
  pages={149-50}
}
NO is an important regulator of cardiovascular remodelling and function. ADMA, an endogenous L-arginine analogue, reduces NO production by inhibiting the activity of NOS. ADMA levels in turn, are regulated by DDAH, which metabolises ADMA. High levels of ADMA and dysregulated DDAH activity are risk factors for cardiovascular disease and morbidity. To… CONTINUE READING