The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif.

@article{Dunckley1999TheDP,
  title={The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif.},
  author={Travis Dunckley and Roy Parker},
  journal={The EMBO journal},
  year={1999},
  volume={18 19},
  pages={5411-22}
}
The major pathway of mRNA degradation in yeast occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body. To identify proteins that control the activity of the decapping enzyme, which is encoded by the DCP1 gene, we isolated a high-copy suppressor of the temperature-sensitive dcp1-2 allele, termed DCP2. Overexpression of Dcp2p partially suppressed the dcp1-2 decapping defect. Moreover, the Dcp2 protein was required for the decapping of both… CONTINUE READING
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A novel context for the ‘ MutT ’ module , a guardian of cell integrity , in a diphosphoinositol polyphosphate phosphohydrolase

S. T. Safranay, J. J. Caffrey, +4 authors S. B. Shears
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A novel context for the ‘MutT’ module, a guardian of cell integrity, in a diphosphoinositol

S. T. Safranay, J. J. Caffrey, +4 authors S. B. Shears
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