The DCC gene product in cellular differentiation and colorectal tumorigenesis.

@article{Hedrick1994TheDG,
  title={The DCC gene product in cellular differentiation and colorectal tumorigenesis.},
  author={Leslie R. Hedrick and Kathleen R. Cho and Eric R. Fearon and Tong Ching Tom Wu and Kenneth W. Kinzler and Bert Vogelstein},
  journal={Genes & development},
  year={1994},
  volume={8 10},
  pages={
          1174-83
        }
}
The analysis of human colorectal tumors has revealed frequent loss of heterozygosity (LOH) of the long arm of chromosome 18. A novel gene, DCC (deleted in colorectal cancer), located within the region of LOH on chromosome 18q was identified and has been implicated as a tumor suppressor gene. We have now shown that DCC encodes a membrane-bound protein of the immunoglobulin-CAM family, as demonstrated by cell-surface labeling, immunohistochemical analysis, and sequencing of cDNA clones. The DCC… CONTINUE READING

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