The DC-HIL/syndecan-4 pathway regulates autoimmune responses through myeloid-derived suppressor cells.

@article{Chung2014TheDP,
  title={The DC-HIL/syndecan-4 pathway regulates autoimmune responses through myeloid-derived suppressor cells.},
  author={Jin-Sung Chung and Kyoichi Tamura and Hideo Akiyoshi and Ponciano D. Cruz and Kiyoshi Ariizumi},
  journal={Journal of immunology},
  year={2014},
  volume={192 6},
  pages={
          2576-84
        }
}
Having discovered that the dendritic cell (DC)-associated heparan sulfate proteoglycan-dependent integrin ligand (DC-HIL) receptor on APCs inhibits T cell activation by binding to syndecan-4 (SD-4) on T cells, we hypothesized that the DC-HIL/SD-4 pathway may regulate autoimmune responses. Using experimental autoimmune encephalomyelitis (EAE) as a disease model, we noted an increase in SD-4(+) T cells in lymphoid organs of wild-type (WT) mice immunized for EAE. The autoimmune disease was also… CONTINUE READING
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