The DAP kinase family of pro-apoptotic proteins: novel players in the apoptotic game.

@article{Kgel2001TheDK,
  title={The DAP kinase family of pro-apoptotic proteins: novel players in the apoptotic game.},
  author={Donat K{\"o}gel and Jochen H. M. Prehn and Karl Heinz Scheidtmann},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2001},
  volume={23 4},
  pages={352-8}
}
The DAP (Death Associated Protein) kinase family is a novel subfamily of pro-apoptotic serine/threonine kinases. All five DAP kinase family members identified to date are ubiquitously expressed in various tissues and are capable of inducing apoptosis. The sequence homology of the five kinases is largely restricted to the N-terminal kinase domain. In contrast, the adjacent C-terminal regions are very diverse and link individual family members to specific signal transduction pathways. There is… CONTINUE READING

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