The D1 agonists SKF 82958 and SKF 77434 are self-administered by rats

@article{Self1992TheDA,
  title={The D1 agonists SKF 82958 and SKF 77434 are self-administered by rats},
  author={David W Self and Larry Stein},
  journal={Brain Research},
  year={1992},
  volume={582},
  pages={349-352}
}
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143 Citations
Highly Influential Citations
5
Background Citations
62
Methods Citations
5
Results Citations
6

143 Citations

Citation Type

Citation Type

Self-administration of the D1 agonist SKF 82958 is mediated by D1, not D2, receptors
TLDR
It is concluded that SKF 82958 self-administration depends on activation of a D1-regulated reinforcement substrate, which is thought to reflect antagonist-induced reductions in drug reinforcement.
Self-administration of D1 receptor agonists by squirrel monkeys
TLDR
The results suggest that the ability of D1 agonists to maintain IV self-administration in squirrel monkeys depends both on the type of schedule and on the pharmacological properties of the particular drug.
Reinforcing effect of the D1 dopamine agonist SKF 81297 in rhesus monkeys
TLDR
It is suggested that stimulation of D1 receptors can initiate a reinforcing effect and further implicate D 1 receptors in the reinforcing effects of drugs that increase dopamine neurotransmission.
Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434.
TLDR
D1 receptor partial agonists can act as functional cocaine antagonists with less severe behavioral effects than D1 receptor antagonists, and the prominent cocaine-antagonist properties and the low incidence of motoric side effects of SKF 83959 may reflect its unique binding profile at D1 as well as nondopaminergic receptors.
Cocaine and SKF-82958 potentiate brain stimulation reward in Swiss-Webster mice
TLDR
The data suggest that SKF-82958 may decrease cocaine-seeking behavior by mechanisms related to reward rather than aversion, and the reward-facilitating effects of low doses of cocaine and SKFs are additive (or synergistic).
The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys.
TLDR
Why some, but not all, D1 receptor agonists can function as reinforcers in rhesus monkeys is examined by comparing behavioral and CNS in vitro measures of potency and efficacy, and reinforcing efficacy among D1 agonists increases with efficacy in stimulating D1 receptors.
Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys
TLDR
Chronic treatment with D1 receptor partial agonists produced dose-dependent effects on cocaine self-administration that may be relevant to their further evaluation as candidate medications for the treatment of cocaine dependence.
Reinforcing effects of D2 dopamine receptor agonists and partial agonists in rhesus monkeys.
Place conditioning with the dopamine D1-like receptor agonist SKF 82958 but not SKF 81297 or SKF 77434.
Comparison of the reinforcing efficacy of two dopamine D2-like receptor agonists in rhesus monkeys using a progressive-ratio schedule of reinforcement
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TLDR
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