The D1 agonists SKF 82958 and SKF 77434 are self-administered by rats

  title={The D1 agonists SKF 82958 and SKF 77434 are self-administered by rats},
  author={David W Self and Larry Stein},
  journal={Brain Research},
Self-administration of the D1 agonist SKF 82958 is mediated by D1, not D2, receptors
It is concluded that SKF 82958 self-administration depends on activation of a D1-regulated reinforcement substrate, which is thought to reflect antagonist-induced reductions in drug reinforcement.
Self-administration of D1 receptor agonists by squirrel monkeys
The results suggest that the ability of D1 agonists to maintain IV self-administration in squirrel monkeys depends both on the type of schedule and on the pharmacological properties of the particular drug.
Reinforcing effect of the D1 dopamine agonist SKF 81297 in rhesus monkeys
It is suggested that stimulation of D1 receptors can initiate a reinforcing effect and further implicate D 1 receptors in the reinforcing effects of drugs that increase dopamine neurotransmission.
Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434.
D1 receptor partial agonists can act as functional cocaine antagonists with less severe behavioral effects than D1 receptor antagonists, and the prominent cocaine-antagonist properties and the low incidence of motoric side effects of SKF 83959 may reflect its unique binding profile at D1 as well as nondopaminergic receptors.
Cocaine and SKF-82958 potentiate brain stimulation reward in Swiss-Webster mice
The data suggest that SKF-82958 may decrease cocaine-seeking behavior by mechanisms related to reward rather than aversion, and the reward-facilitating effects of low doses of cocaine and SKFs are additive (or synergistic).
The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys.
Why some, but not all, D1 receptor agonists can function as reinforcers in rhesus monkeys is examined by comparing behavioral and CNS in vitro measures of potency and efficacy, and reinforcing efficacy among D1 agonists increases with efficacy in stimulating D1 receptors.
Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys
Chronic treatment with D1 receptor partial agonists produced dose-dependent effects on cocaine self-administration that may be relevant to their further evaluation as candidate medications for the treatment of cocaine dependence.
Reinforcing effects of D2 dopamine receptor agonists and partial agonists in rhesus monkeys.


Intravenous self-administration of dopamine receptor agonists by rhesus monkeys.
The results suggest that a DA receptor that is similar to the DA2 receptor is involved in the reinforcing properties of psychomotor stimulants in rhesus monkeys, and are consistent with the hypothesis that CNS DA is involvement in the reinforcement properties of Psychomotor Stimulants.
Receptor subtype-specific dopaminergic agents and conditioned behavior
Receptor subtypes in opioid and stimulant reward.
The reward-relevant opioid and dopamine receptors, as well as the cannabinoid (marijuana) receptor, share the ability to couple Gi proteins that mediate inhibition of adenylate cyclase and stimulation of K+ conductance and may be generally implicated in the reinforcing properties of diverse drugs of abuse.
Subtypes of dopamine receptors involved in the mechanism of reinforcement
  • S. Nakajima
  • Biology, Psychology
    Neuroscience & Biobehavioral Reviews
  • 1989