The D1 Dopamine Receptor Is Constitutively Phosphorylated by G Protein-Coupled Receptor Kinase 4

@article{Rankin2006TheDD,
  title={The D1 Dopamine Receptor Is Constitutively Phosphorylated by G Protein-Coupled Receptor Kinase 4},
  author={Michele L. Rankin and Paul S. Marinec and David M. Cabrera and Zheng Wang and Pedro A. Jose and David R. Sibley},
  journal={Molecular Pharmacology},
  year={2006},
  volume={69},
  pages={759 - 769}
}
G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate agonist-activated GPCRs, initiating their homologous desensitization. In this article, we present data showing that GRK4 constitutively phosphorylates the D1 receptor in the absence of agonist activation. This constitutive phosphorylation is mediated exclusively by the α isoform of GRK4; the β, γ, and δ isoforms are ineffective in this regard. Mutational analysis reveals that the constitutive phosphorylation mediated by GRK4α is… 
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