• Medicine
  • Published in
    The Journal of rheumatology…
    2005

The D-hormone analog alfacalcidol: the pioneer beyond the horizon of osteoporosis treatment.

@article{Orimo2005TheDA,
  title={The D-hormone analog alfacalcidol: the pioneer beyond the horizon of osteoporosis treatment.},
  author={Hajime Orimo and Erich Schacht},
  journal={The Journal of rheumatology. Supplement},
  year={2005},
  volume={76},
  pages={
          4-10
        }
}
Over the last 30 years, several clinical trials have reported the efficacy of D-hormone analogs to treat primary and secondary osteoporosis, and their genomic and nongenomic mode of action have been demonstrated with the progress of biochemical research technologies. Recent metaanalyses reviewed the preventive effect on falls and fractures of "vitamin D3" in the elderly population, mainly based on studies with alfacalcidol and calcitriol. In future a clear differentiation must be made between… CONTINUE READING

Citations

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Additive effects of eldecalcitol in poorly responding long-term bisphosphonate treatment for osteoporosis

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Transcriptional activation of the wild-type and mutant vitamin D receptors by vitamin D3 analogs.

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