The D-channel of cytochrome oxidase: an alternative view.

@article{Wikstrm2011TheDO,
  title={The D-channel of cytochrome oxidase: an alternative view.},
  author={M{\aa}rten Wikstr{\"o}m and Michael I. Verkhovsky},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1807 10},
  pages={
          1273-8
        }
}
The D-pathway in A-type cytochrome c oxidases conducts protons from a conserved aspartate on the negatively charged N-side of the membrane to a conserved glutamic acid at about the middle of the membrane dielectric. Extensive work in the past has indicated that all four protons pumped across the membrane on reduction of O(2) to water are transferred via the D-pathway, and that it is also responsible for transfer of two out of the four "chemical protons" from the N-side to the binuclear oxygen… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Proton Pumping in Cytochrome c Oxidase

VIEW 1 EXCERPT
CITES BACKGROUND

Characterizing the proton loading site in cytochrome c oxidase.

  • Jianxun Lu, M. R. Gunner
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2014
VIEW 1 EXCERPT
CITES BACKGROUND

Functions of the hydrophilic channels in protonmotive cytochrome c oxidase

VIEW 2 EXCERPTS
CITES BACKGROUND