The D-amino acid peptide D3 reduces amyloid fibril boosted HIV-1 infectivity

@inproceedings{Widera2014TheDA,
  title={The D-amino acid peptide D3 reduces amyloid fibril boosted HIV-1 infectivity},
  author={Marek Widera and Antonia Nicole Klein and Yeliz Cinar and Susanne Aileen Funke and Dieter Willbold and Heiner Schaal},
  booktitle={AIDS research and therapy},
  year={2014}
}
BACKGROUND Amyloid fibrils such as Semen-Derived Enhancer of Viral Infection (SEVI) or amyloid-β-peptide (Aβ) enhance HIV-1 attachment and entry. Inhibitors destroying or converting those fibrils into non-amyloidogenic aggregates effectively reduce viral infectivity. Thus, they seem to be suitable as therapeutic drugs expanding the current HIV-intervening repertoire of antiretroviral compounds. FINDINGS In this study, we demonstrate that the small D-amino acid peptide D3, which was… CONTINUE READING