The D-alanine residues of Staphylococcus aureus teichoic acids alter the susceptibility to vancomycin and the activity of autolytic enzymes.

@article{Peschel2000TheDR,
  title={The D-alanine residues of Staphylococcus aureus teichoic acids alter the susceptibility to vancomycin and the activity of autolytic enzymes.},
  author={Andreas Peschel and Cuong Van Vuong and Michael Otto and Friedrich G{\"o}tz},
  journal={Antimicrobial agents and chemotherapy},
  year={2000},
  volume={44 10},
  pages={
          2845-7
        }
}
Recently, Staphylococcus aureus strains with intermediate resistance to vancomycin, the antibiotic of last resort, have been described. Multiple changes in peptidoglycan turnover and structure contribute to the resistance phenotype. Here, we describe that structural changes of teichoic acids in the cell envelope have a considerable influence on the susceptibility to vancomycin and other glycopeptides. S. aureus cells lacking D-alanine esters in teichoic acids exhibited an at least threefold… CONTINUE READING
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