The Cytotoxicity of Elderberry Ribosome-Inactivating Proteins Is Not Solely Determined by Their Protein Translation Inhibition Activity

@inproceedings{Shang2015TheCO,
  title={The Cytotoxicity of Elderberry Ribosome-Inactivating Proteins Is Not Solely Determined by Their Protein Translation Inhibition Activity},
  author={Chenjing Shang and Qiushi Chen and Anne Dell and Stuart M. Haslam and Winnok H De Vos and Els J. M. van Damme and Nicholas J Mantis},
  booktitle={PloS one},
  year={2015}
}
Although the protein translation inhibition activity of ribosome inactivating proteins (RIPs) is well documented, little is known about the contribution of the lectin chain to the biological activity of these proteins. In this study, we compared the in vitro and intracellular activity of several S. nigra (elderberry) RIPs and non-RIP lectins. Our data demonstrate that RIPs from elderberry are much more toxic to HeLa cells than to primary fibroblasts. Differences in the cytotoxicity between the… CONTINUE READING
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