The Cytotoxic Effect of Bromoenol Lactone, a Calcium-independent Phospholipase A2 Inhibitor, on Rat Cortical Neurons in Culture

@article{Kurusu2008TheCE,
  title={The Cytotoxic Effect of Bromoenol Lactone, a Calcium-independent Phospholipase A2 Inhibitor, on Rat Cortical Neurons in Culture},
  author={Shiro Kurusu and Kohtaro Matsui and Toshimichi Watanabe and Toshinobu Tsunou and Mitsumori Kawaminami},
  journal={Cellular and Molecular Neurobiology},
  year={2008},
  volume={28},
  pages={1109-1118}
}
This study characterized the phospholipase A2 (PLA2) activity in cerebral cortex of fetal rat brain and investigated effects of chemical inhibition of Ca2+-independent PLA2 (iPLA2) on neurite outgrowth and cell development of cortical neurons in vitro. The PLA2 activity in fetal brain was insensitive to a Ca2+-chelator EGTA and was significantly impaired by an iPLA2 inhibitor, bromoenol lactone (BEL). Following treatment with BEL, cortical neurons showed acute loss of neurites and impaired cell… CONTINUE READING

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