The Cytokinetics of Monocytosis in Acute Salmonella Infection in the Rat

  title={The Cytokinetics of Monocytosis in Acute Salmonella Infection in the Rat},
  author={Alvin Volkman and Frank M. Collins},
  journal={The Journal of Experimental Medicine},
  pages={264 - 277}
The mechanisms responsible for monocytosis occurring in acute Salmonella infection were studied by means of isotopic labeling and autoradiography. Male (Lewis x BN)F(1) hybrid rats (160-180 g) were pulse-labeled with [(3)H]TdR at varying intervals with respect to the time of i.v. injection of about 10(6) living Salmonella enteritidis. The half time for monocytes in the blood was estimated from the exponential decline in the percentage of labeled monocytes. The average generation time for… CONTINUE READING
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