The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function.

@article{Connolly2004TheCS,
  title={The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function.},
  author={Christopher N. Connolly and Keith A Wafford},
  journal={Biochemical Society transactions},
  year={2004},
  volume={32 Pt3},
  pages={
          529-34
        }
}
The Cys-loop receptors constitute an important superfamily of LGICs (ligand-gated ion channels) comprising receptors for acetylcholine, 5-HT3 (5-hydroxytryptamine; 5-HT3 receptors), glycine and GABA (gamma-aminobutyric acid; GABAA receptors). A vast knowledge of the structure of the Cys-loop superfamily and its impact on channel function have been accrued over the last few years, leading to exciting new proposals on how ion channels open and close in response to agonist binding. Channel opening… CONTINUE READING

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